B-CAG-hCLDN18.2 MC38 Cell Line

Basic Information

Strain Name
MC38 Gt (ROSA)26Sor tm3(CAG-CLDN18.2)Bcgen
Stock Number
310715
Common Name
B-CAG-hCLDN18.2 MC38 Cell Line
Disease
Colorectal cancer
Species
Mus musculus, mouse (C57BL/6J)
Growth factors
Adherent
Culture medium
DMEM+10%FBS
Frozen
90% Complete medium+10% DMSO

Targeting Strategy

B-CAG-hCLDN182-MC38-Cell-Line-targeting-strategy

Details

Phenotyping Information

Phenotypic analysis of B-CAG-hCLDN18.2 MC38 Cell Line

B-CAG-hCLDN182-MC38-Cell-Line-details-Phenotypic-analysis

B-CAG-hCLDN18.2 MC38 Cell Line were analyzed by flow cytometry. The hCLDN18.2 protein was detected in B-CAG-hCLDN18.2 MC38 Cell Line.

Tumor Growth Curve

B-CAG-hCLDN182-MC38-Cell-Line-details-growth-tumor-curve

C57BL/6 mice were subcutaneously injected with tumor cells (5E5) in the right front flank for tumor development. Tumor size was measured two times weekly in two dimensions using a caliper, and the volume was expressed in mm3 using the formula: V=0.5a X b 2 where a and b were the long and short diameters of the tumor, respectively.

Tumor Cells Analysis

B-CAG-hCLDN182-MC38-Cell-Line-details-tumor-cells-analysis

B-CAG-hCLDN18.2 MC38 Cells were subcutaneously implanted into C57BL/6 mice. Mice were divided into control and treatment groups (n=7), when the tumor size was approximately 150±50 mm3. hCLDN18.2 antibody showed substantially inhibitory effects in the mouse model. (A) Tumor average volume ± SEM, (B) Mice average weight ± SEM.

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