B-hCTLA4/h4-1BB Mice

Basic Information

Strain Name
C57BL/6-Ctla4tm1(CTLA4) Cd137tm1(CD137)/Bcgen
Stock Number
120539
Common Name
B-hCTLA4/h4-1BB Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
CTLA4 (Cytotoxic T-lymphocyte-associated protein 4, CD152) TNFRSF9 (Tumor necrosis factor receptor superfamily, member 9)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

B-hCTLA4/h4-1BB Mice

Details

Phenotype

Protein Expression Analysis

B-hCTLA4/h4-1BB Mice

Splenocytes from homozygous B-hCTLA4/h4-1BB mice were analyzed by flow cytometry. m4-1BB+ cells were detectable in wild type (WT) C57BL/6, h4-1BB+ cells were detectable in the homozygous B-hCTLA4/h4-1BB mice

B-hCTLA4/h4-1BB Mice

Splenocytes from homozygous B-hCTLA4/h4-1BB mice were analyzed by flow cytometry. mCTLA4+ cells were detectable in wild type (WT) C57BL/6, while hCTLA4+ cells were detectable in the homozygous B-hCTLA4/h4-1BB mice.

References

  1. J Immunol.1991 Aug 1;147(3):1037-44.
  2. J Exp Med.1991 Sep 1;174(3):561-9.
  3. PLoS One. 2014 Jan 21;9(1): e86337.
  4. Cancer Gene Ther. 2004 Mar;11(3):215-26.
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