Protein Expression Analysis
Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hCTLA4/hLAG3 mice were analyzed by flow cytometry.
Mouse LAG3+ T cells were detectable in both WT C57BL/6 and the homozygous B-hCTLA4/hLAG3 mice, while human LAG3+ T cells were detectable in the homozygous B-hCTLA4/hLAG3 mice. This might result from the cross-recognition of hLAG3 by anti-mLAG3 antibodies.
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