B-hPD-1/hCD27 Mice

Basic Information

Strain Name
C57BL/6-Pdcd1tm1(PDCD1) Cd27tm1(CD27)/Bcgen
Stock Number
120518
Common Name
B-hPD-1/hCD27 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
PD-1(Programmed death-1); CD27(CD27 molecule) Species: C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

Details

Phenotype

Protein Expression Analysis

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse CD27+ T cells were detectable in both WT C57BL/6 and the homozygous B-hPD-1/hCD27 mice, while human CD27+ T cells were detectable in the homozygous B-hPD-1/hCD27 mice. This might result from the cross-recognition of hCD27 by anti-mCD27 antibodies.

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-1/hCD27 mice were analyzed by flow cytometry. Mouse PD-1+ T cells were detectable in the WT C57BL/6 mice, while human PD-1+ T cells were detectable in the homozygous B-hPD-1/hCD27 mice.

References

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