B-hPD-L1/h4-1BB Mice

Basic Information

Strain Name
C57BL/6-Cd274tm1(CD274) Cd137tm1(CD137)/Bcgen
Stock Number
120535
Common Name
B-hPD-L1/h4-1BB Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Cd274 (CD274 antigen) Tnfrsf9 (tumor necrosis factor receptor superfamily, member 9)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous
Gene Description

Targeting Strategy

B-hPD-L1/h4-1BB Mice

Details

Phenotype

Protein Expression Analysis

B-hPD-L1/h4-1BB Mice

Splenocytes from B-hPD-L1/h4-1BB mice were analyzed by flow cytometry.

m4-1BB+ cells were detectable in the WT C57BL/6 mice, while h4-1BB+ cells were detectable in the homozygous B-hPD-L1/h4-1BB mice.

B-hPD-L1/h4-1BB Mice

Splenocytes from B-hPD-L1/h4-1BB mice were analyzed by flow cytometry.

mPD-L1+ cells were detectable in the WT C57BL/6 mice, while hPD-L1+ cells were detectable in the homozygous B-hPD-L1/h4-1BB mice.

References

  1. Trends Mol Med.2015 Jan;21(1):24-33. doi: 10.1016/j.molmed.2014.10.009. Epub 2014 Oct 30.
  2. Proc Natl Acad Sci U S A.2008 Feb 26;105(8):3011-6. doi: 10.1073/pnas.0712278105. Epub 2008 Feb 14.
  3. PLoS One.2014 Jan 21;9(1):e86337. doi: 10.1371/journal.pone.0086337. eCollection 2014
  4. Cancer Gene Ther. 2004 Mar;11(3):215-26.
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