B-hPD-L1/hCTLA4 Mice

Basic Information

Strain Name
C57BL/6-Cd274tm1(CD274) Ctla4tm1(CTLA4)/Bcgen
Stock Number
120538
Common Name
B-hPD-L1/hCTLA4 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Ctla4 (cytotoxic T-lymphocyte-associated protein 4); Cd274 (CD274 antigen)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

Details

Protein Expression Analysis

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-L1/hCTLA4 mice were analyzed by flow cytometry.Mouse PD-L1+ T cells were detectable in the WT mice, while human PD-L1+ T cells were detectable in the homozygous B-hPD-L1 /hCTLA4 mice.

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-L1 /hCTLA4 mice were analyzed by flow cytometry. Mouse CTLA4+ T cells were detectable in the WT mice, while human CTLA4+ T cells were detectable in the homozygous B-hPD-L1 /hCTLA4 mice.

References

  1. Clin Cancer Res 2016; published online Nov 8. DOI:10.1158/1078-0432.CCR-16-1741
  2. Blood First Edition paper, May 11, 2010; DOI 10.1182/blood-2010-02-271874.
  3. Cell Research (2018) 0:1–15; doi: 10.1038/s41422-018-0012-z
  4. Cancer Immunity (22 January 2013) Vol. 13, p. 5
Back to top