B-hPD-L1/hLAG3 Mice

Basic Information

Strain Name
C57BL/6-Cd274 tm1(CD274) Lag3 tm1(LAG3) /Bcgen
Stock Number
120533
Common Name
B-hPD-L1/hLAG3 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Cd274 (CD274 antigen) Lag3 (lymphocyte-activation gene 3)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

Details

Phenotype

Protein Expression Analysis

Splenocytes B-hPD-L1/hLAG3 mice were analyzed by flow cytometry. mLAG3+
cells were detectable in C57BL/6 mice, while hLAG3 + cells were detectable in the
homozygous B-hPD-L1/hLAG3 mice. Detection of mLAG3 + cells in B-hPD-
L1/hLAG3 mice might caused by mouse antibody cross reactivity.

Splenocytes B-hPD-L1/hLAG3 mice were analyzed by flow cytometry. mPD-L1 +
cells were detectable in C57BL/6 mice, while hPD-L1 + cells were detectable in
the homozygous B-hPD-L1/hLAG3 mice.

 

References

  1. J Immunol Methods. 2017 Aug;447:47-51. doi: 10.1016/j.jim.2017.04.006. Epub 2017 Apr 21.
  2. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5744-9.
  3. Nat Immunol. 2001 Dec;2(12):1109-16.
  4. Immunity. 2007 Mar;26(3):311-21.
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