B-hPD-L1/hOX40 Mice

Basic Information

Strain Name
C57BL/6-Cd274tm1(CD274) Tnfrsf4tm1(TNFRSF4)/Bcgen
Stock Number
120534
Common Name
B-hPD-L1/hOX40 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Cd274 (CD274 antigen) Tnfrsf4 (tumor necrosis factor receptor superfamily, member 4)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

Details

Phenotype

Protein Expression Analysis

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-L1/hOX40 mice were analyzed by flow cytometry. Mouse OX40+ T cells were detectable in the WT C57BL/6 mice, while human OX40+ T cells were detectable in the homozygous B-hPD-L1/hOX40 mice.

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hPD-L1/hOX40 mice were analyzed by flow cytometry.Mouse PD-L1+ T cells were detectable in the WT mice, while human PD-L1+ T cells were detectable in the homozygous B-hPD-L1/hOX40 mice.

References

  1. Nat Rev Immunol. 2004 Jun;4(6):420-31.
  2. Structure. 2006 Aug;14(8):1321-30.
  3. Immunol Rev. 2011 Nov;244(1):218-31. doi: 10.1111/j.1600-065X.2011.01069.x.
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