Basic Information

Strain Name
C57BL/6-Lepr tm1( /Bcgen
Stock Number
B-CM-012
Common Name
B-db/db Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Lepr (leptin receptor)
Species
C57BL/6
Appearance
Black
Genotypes
Heterozygote
Development
B-db/db mice were developed by Beijing Biocytogen Co., Ltd. The Exons 5-7 of mice were knocked out. With obesity and hyperglycemia, it is a powerful model for studying hyperglycemia and obesity.

Description

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively, spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins.

Targeting Strategy

B-dbdb-mice-Targeting-Strategy

Details

Physiological analysis

B-db/db mice weight detection

B-dbdb-mice-Details

The weight of the homozygous B-db/db mice were continuously higher than that
of the control group at the age of 7 weeks;

B-db/db mice blood glucose test

B-dbdb-mice-Blood glucose test

Blood glucose: the blood glucose of the homozygous B-ob/ob mice (-/-) were
continuously higher than that of the control group at the age of 7 weeks.

References

https://www.ncbi.nlm.nih.gov/pubmed/30231898/

https://www.ncbi.nlm.nih.gov/pubmed/30126176/

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