Basic Information

Strain name
C57BL/6-Igh-Jtm1/Bcgen
Common name
B-Igh-J KO mice
Background
C57BL/6
Catalog number
111116
Related gene
Igh-J (immunoglobulin heavy chain, joining region)
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-Igh-J KO mice. The exons of mouse Ighd4-1 and Ighj1-4 gene were knockout in B-Igh-J KO mice.

Protein expression analysis

Strain specific analysis of IgD and IgM expression in WT and the homozygous B-Igh-J KO mice by flow cytometry. Spleen were collected from WT mice and homozygous B-Igh-J KO mice (-/-). Mouse IgD and IgM were detectable in WT mice but not the homozygous B-Igh-J KO mice.

Strain specific analysis of IgD and IgM expression in WT and the homozygous B-Igh-J KO mice by flow cytometry. Bone marrow were collected from WT mice and homozygous B-Igh-J KO mice (-/-). Mouse IgD and IgM were detectable in WT mice but not the homozygous B-Igh-J KO mice.