The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively, spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins.
B-db/db mice weight detection
The weight of the homozygous B-db/db mice were continuously higher than that
of the control group at the age of 7 weeks;
B-db/db mice blood glucose test
Blood glucose: the blood glucose of the homozygous B-ob/ob mice (-/-) were
continuously higher than that of the control group at the age of 7 weeks.