The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis.
B-ob/ob mice weight detection
The weight of the homozygous B-ob/ob mice were continuously higher than that of the control group at the age of 4 weeks;
B-ob/ob mice blood glucose test
Blood glucose: the blood glucose of the homozygous B-ob/ob mice (-/-) were continuously higher than that of the control group at the age of 4 weeks.
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