Basic Information

Strain Name
C57BL/6-Leptin tm1 /Bcgen
Stock Number
110172
Common Name
B-ob/ob mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Lep (leptin)
Species
C57BL/6
Appearance
Black
Genotypes
Heterozygote
Development
B-ob/ob mice were developed by Beijing Biocytogen Co., Ltd. Exons 2-3 of mice Lep (leptin) were knocked out.
NCBI Gene ID

Description

B-ob/ob mice are a powerful model for studying hyperglycemia and obesity.

Targeting Strategy

Details

Physiological analysis

B-ob/ob mice weight detection

B-obob-mice-Details

The weight of the homozygous B-ob/ob mice were continuously higher than that of the control group at the age of 4 weeks;

B-ob/ob mice blood glucose test

B-obob mice-blood-glucose-test

Blood glucose: the blood glucose of the homozygous B-ob/ob mice (-/-) were continuously higher than that of the control group at the age of 4 weeks.

References

1. Leptin receptor gene polymorphisms and sex modify the association between
acetaminophen use and asthma among young adults: results from two observational studies.Ziyab AH, et al. Respir Res, 2018 Sep 19. PMID 30231898.
2. Food Consumption as a Modifier of the Association between LEPR Gene Variants and Excess Body Weight in Children and Adolescents: A Study of the SCAALA Cohort.Dos Santos Rocha A, et al. Nutrients, 2018 Aug 18. PMID 30126176.