Basic Information

Strain name
C57BL/6-Adipoqtm1(ADIPOQ)Bcgen/Bcgen
Common Name
B-hADIPOQ mice
Background
C57BL/6
Catalog Number
111594
Aliases
ADIPQ: ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hADIPOQ mice. The exons 2~3 of mouse Adipoq gene that encode the extracellular domain were replaced by human ADIPOQ exons 2~3 in B-hADIPOQ mice.

Protein expression analysis

Strain specific ADIPOQ expression analysis in homozygous B-hADIPOQ mice by ELISA. Plasma were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hADIPOQ mice (H/H), and analyzed by ELISA with species-specific ADIPOQ ELISA kit. Mouse ADIPOQ was detectable in wild-type mice (A). Human ADIPOQ was exclusively detectable in homozygous B-hADIPOQ mice but not in wild-type mice (B).

Summary

Protein expression analysis:

Human ADIPOQ was only detectable in plasma of homozygous B-hADIPOQ mice, and mouse Adipoq was only detectable in wild-type C57BL/6 mice.

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