Basic Information

Strain name
C57BL/6-Albtm1(ALB)/Bcgen
Common name
B-hALB mice
Catalog number
110960
Background
C57BL/6
Related genes
Albumin, Al; Alb1; Alb-1; BCL002

Description

Albumin is a family of globular proteins, the most common of which are the serum albumins. It is the most abundant protein in human blood plasma; it constitutes about half of serum protein. It is produced in the liver. It is soluble in water, and it is monomeric. Albumin is a natural transport protein with multiple ligand binding sites, cellular receptor engagement, and a long circulatory half-life due to interaction with the recycling neonatal Fc receptor.  Albumin has long been the center of attention in the pharmaceutical industry due to its ability to bind to various drug molecules, its stability during storage and in vivo usage, and lack of toxicity and antigenicity.

Target Strategy

The exons 1-14 of mouse Alb gene that encode the full-length protein were replaced by human ALB exons 1-14 in B-hALB mice.

Protein expression analysis

Strain specific ALB expression analysis in heterozygous B-hALB mice by ELISA.

Serum was collected from C57BL/6 wild-type mice (+/+) and heterozygous B-hALB mice (H/+) analyzed by ELISA with species-specific ALB ELISA kit. Mouse ALB were both detectable in wild-type mice and heterozygous B-hALB mice. Human ALB was exclusively detectable in heterozygous B-hALB mice but not in wild-type mice. ND: not detected.