Basic Information

Strain Name
C57BL/6-Angpt2tm2(ANGPT2)/Bcgen
Common Name
B-hANG2 mice
Background
C57BL/6J
Catalog number
112028
Aliases
ANGPT2
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hANG2 mice.  Exons 1-9 of mouse Angpt2 gene that encode the full-length protein were replaced by human ANGPT2 exons 1-9 in B-hANG2 mice.

Protein expression analysis

Species-specific ANG2 protein expression analysis in humanized B-hANG2 mice. Plasma was collected from wild-type C57BL/6 (+/+) and heterozygous B-hANG2 (H/+) mice and analyzed by ELISA using species-specific ANG2 kits. Murine ANG2 protein was detected in wild-type and B-hANG2 mice, while human ANG2 protein was only detected in B-hANG2 mice. Values are expressed as mean ± SEM. ND: not detectable.