Basic Information
Strain name
C57BL/6-Angptl3tm4(ANGPTL3)/Bcgen
Common Name
B-hANGPTL3 mice plus
Background
C57BL/6N
Catalog Number
112523
Aliases
ANGPTL3(ANL3, ANG-5, FHBL2, ANGPT5)
NCBI Gene ID
-
Gene targeting strategy
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Gene targeting strategy for B-hANGPTL3 mice plus. The genome of mouse Angptl3 gene including 3’UTR was replaced by human ANGPTL3 genome including 3’UTR in B-hANGPTL3 mice plus.
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Protein expression analysis
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Species-specific ANGPTL3 protein expression analysis in wild-type and humanized B-hANGPTL3 mice plus. Plasma was collected from wild-type C57BL/6 (+/+) and homozygous B-hANGPTL3 (H/H) mice plus and analyzed by ELISA using species-specific ANGPTL3 kits. Mouse ANGPTL3 was detected in wild-type mice, while human ANGPTL3 was detected in B-hANGPTL3 mice plus.
