B-hANGPTL3 mice plus
ANGPTL3(ANL3, ANG-5, FHBL2, ANGPT5)
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hANGPTL3 mice plus. The genome of mouse Angptl3 gene including 3’UTR was replaced by human ANGPTL3 genome including 3’UTR in B-hANGPTL3 mice plus.
Protein expression analysis
Species-specific ANGPTL3 protein expression analysis in wild-type and humanized B-hANGPTL3 mice plus. Plasma was collected from wild-type C57BL/6 (+/+) and homozygous B-hANGPTL3 (H/H) mice plus and analyzed by ELISA using species-specific ANGPTL3 kits. Mouse ANGPTL3 was detected in wild-type mice, while human ANGPTL3 was detected in B-hANGPTL3 mice plus.