Basic Information

Strain Name
C57BL/6-Angptl3tm1(ANGPTL3)/Bcgen
Common Name
B-hANGPTL3 mice
Background
C57BL/6N
Catalog number
112224
Aliases
ANGPTL3(ANL3, ANG-5, FHBL2, ANGPT5)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hANGPTL3 mice. The exons 1-7 of mouse Angptl3 gene that encodes the full-length protein was replaced by human ANGPTL3 exons 1-7 in B-hANGPTL3 mice.

Protein expression analysis

Species-specific ANGPTL3 protein expression analysis in wild-type and humanized B-hANGPTL3 mice. Plasma was collected from wild-type C57BL/6 (+/+) and heterozygous B-hANGPTL3 (H/+) mice and analyzed by ELISA using species-specific anti-ANGPTL3 kits. Murine ANGPTL3 protein was detected in wild-type and B-hANGPTL3 mice, while human ANGPTL3 protein was only detected in B-hANGPTL3 mice.