Basic Information

Strain Name
C57BL/6N-Tnfrsf13ctm1(TNFRSF13C)/Bcgen
Common Name
B-hBAFFR mice
Background
C57BL/6N
Catalog number
111140
Aliases
TNFRSF13C, BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin, TNF receptor superfamily member 13C
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hBAFFR mice.

The exons 1-2 of mouse Tnfrsf13c gene that encode the extracellular domain and transmembrane domain were replaced by human TNFRSF13C exons 1-2 in B-hBAFFR mice.

Protein expression analysis

Strain specific BAFFR expression analysis in homozygous B-hBAFFR mice by flow cytometry.

Splenocytes were collected from WT and homozygous B-hBAFFR (H/H) mice, and analyzed by flow cytometry with species-specific anti-BAFFR antibody. Mouse BAFFR was detectable in WT mice. Human BAFFR was exclusively detectable in homozygous B-hBAFFR but not WT mice.

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