Basic Information

Strain name
C57BL/6N-Ccl11tm1(CCL11)Bcgen/Bcgen
Common Name
B-hCCL11 mice
Background
C57BL/6N
Catalog Number
111404
Aliases
CCL11(SCYA11)
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hCCL11 mice. The exons 1-3 of mouse Ccl11 gene that encode the full-length protein were replaced by human CCL11 exons 1-3 in B-hCCL11 mice.

Protein expression analysis in serum

Strain specific CCL11 expression analysis in homozygous B-hCCL11 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hCCL11 mice (H/H), and analyzed by ELISA with species-specific CCL11 ELISA kit. Mouse CCL11 was detectable only in wild-type mice. Human CCL11 was detectable in homozygous B-hCCL11 mice but not in wild-type mice.

Summary

Protein expression analysis:

Human CCL11 was detectable in homozygous B-hCCL11 mice but not in wild-type mice, and mouse CCL11 was detectable only in wild-type mice.

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