Basic Information
Strain name
C57BL/6-Ccl24tm1(Ccl24)/Bcgen
Common Name
B-hCCL24 mice
Background
C57BL/6N
Catalog Number
111396
Aliases
CCL24: Ckb-6, MPIF2, MPIF-2, SCYA24
NCBI Gene ID
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Targeting strategy
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Gene targeting strategy for B-hCCL24 mice.
The exons 1-3 of mouse Ccl24 gene that encodes the full-length protein was replaced by human CCL24 exons 1-3 in B-hCCL24 mice.
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Protein expression analysis
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Strain specific CCL24 expression analysis in homozygous B-hCCL24 mice by ELISA. Serum were isolated from wild-type C57BL/6N mice (+/+) and homozygous B-hCCL24 mice (H/H), and analyzed by ELISA with species-specific CCL24 ELISA kit. Mouse CCL24 was detectable in wild-type mice (A). Human CCL24 was exclusively detectable in homozygous B-hCCL24 mice but not in wild-type mice (B).
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Summary
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Protein expression analysis:
Human CCL24 was only detectable in serum of homozygous B-hCCL24 mice, and mouse Ccl24 was only detectable in wild-type C57BL/6N mice.
