Basic Information

Strain Name
C57BL/6N-Ifnb1tm1(IFNB1)Bcgen/Bcgen
Common Name
B-hIFNB1 mice
Background
C57BL/6N
Catalog number
111210
Aliases
IFB; IFF; IFNB; IFN-beta
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hIFNB1 mice. The full coding sequence of mouse Ifnb1 was replaced by human IFNB1 coding sequences in B-hIFNB1 mice, so the mouse Ifnb1 gene was disrupted.

Protein expression analysis

Strain specific IFNB1 expression analysis in homozygous B-hIFNB1 mice by ELISA. Serum were collected from wild type (+/+) and homozygous B-hIFNB1 mice (H/H) stimulated with LPS for 2 hours in vivo, and analyzed by ELISA with species-specific IFNB1 ELISA kit. Mouse IFNB1 was detectable in wild type mice. Human IFNB1 was exclusively detectable in homozygous B-hIFNB1 mice but not in wild type mice.

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