Basic Information
Strain Name
C57BL/6-Il10tm1(IL10)Bcgen/Bcgen
Common Name
B-hIL10 mice
Background
C57BL/6
Catalog number
110060
Related Genes
Il10 (interleukin 10)
NCBI Gene ID
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mRNA expression analysis
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Strain specific analysis of IL10 gene expression in WT and hIL10 mice by RT-PCR. Mouse Il10 mRNA was detectable in splenocytes of wild-type (+/+) mice, Human IL10 mRNA was detectable only in homozygous (H/H) mice but not WT mice.
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Protein expression analysis
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Serum from both wild type (WT) C57BL/6 and homozygous B-hIL10 mice were analyzed by ELISA. When treated with LPS, mouse IL10 was only detectable in WT C57BL/6 mice, while human IL10 was only detectable in homozygous B-hIL10 mice. n=3.