Basic Information

Strain name
C57BL/6-Il17ratm1(IL17RA)/Bcgen
Common name
B-hIL17RA mice
Catalog number
110054
Background
C57BL/6
Aliases
IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, interleukin 17 receptor A

Description

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL – 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

Targeting strategy

The exons 2-9 of mouse Il17ra gene that encode the extracellular domain were replaced by human IL17RA exons 2-9 in B-hIL17RA mice.

Protein expression analysis in granulocytes

Strain specific IL17RA expression analysis in heterozygous B-hIL17RA mice by flow cytometry.

Bone marrow  were collected from WT and heterozygous B-hIL17RA (H/+) mice, and analyzed by flow cytometry with species-specific anti-IL17RA antibody. Mouse IL17RA was detectable in WT and heterozygous B-hIL17RA mice. Human IL17RA was exclusively detectable in heterozygous B-hIL17RA but not WT mice.