Basic Information

Strain name
C57BL/6-Il17ratm1(IL17RA)/Bcgen
Common name
B-hIL17RA mice
Catalog number
110054
Background
C57BL/6J
NCBI Gene ID
Aliases
IL17RA, CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R, interleukin 17 receptor A

Targeting strategy

The exons 2-9 of mouse Il17ra gene that encode the extracellular domain were replaced by human IL17RA exons 2-9 in B-hIL17RA mice.

Protein expression analysis in granulocytes

Strain specific IL17RA expression analysis in heterozygous B-hIL17RA mice by flow cytometry.

Bone marrow  were collected from WT and heterozygous B-hIL17RA (H/+) mice, and analyzed by flow cytometry with species-specific anti-IL17RA antibody. Mouse IL17RA was detectable in WT and heterozygous B-hIL17RA mice. Human IL17RA was exclusively detectable in heterozygous B-hIL17RA but not WT mice.