Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.
mRNA expression analysis
Strain specific analysis of IL1RAcP gene expression in WT and hIL1RAcP mice by RT-PCR. Mouse IL1RAcP mRNA was detectable in liver of wild-type (+/+) and homozygous (H/H) mice. Human IL1RAcP mRNA was detectable only in H/h but not in +/+ mice.