B-hIL1RAcP mice

Basic Information

Strain Name
C57BL/6-IL1RAcPtm1(hIL1RAcP)/Bcgen
Stock Number
110072
Common Name
B-hIL1RAcP mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
IL1RAP; IL1R3; C3orf13
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Description

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.

Details

mRNA expression analysis

Strain specific analysis of IL1RAcP gene expression in WT and hIL1RAcP mice by RT-PCR. Mouse IL1RAcP mRNA was detectable in liver of wild-type (+/+) and homozygous (H/H) mice. Human IL1RAcP mRNA was detectable only in H/h but not in +/+ mice.

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