Basic Information
Strain Name
C57BL/6-Il2tm1(IL2)/Bcgen
Common Name
B-hIL2 mice
Background
C57BL/6
Catalog Number
110085
Related Gene
IL2 (Interleukin-2)
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hIL2 mice. The targeted mouse Il2 whole genomic sequence was replaced by human IL2 whole genomic sequence in B-hIL2 mice.
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Protein expression analysis
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Strain specific IL2 expression analysis in heterozygous B-hIL2 mice by ELISA.
Serum were collected from WT and heterozygous B-hIL2 (H/+) mice stimulated with anti-CD3ε and anti-CD28 in vivo, and analyzed by ELISA with species-specific IL2 ELISA kit. Mouse IL2 was detectable in WT and heterozygous B-hIL2 mice. Human IL2 was exclusively detectable in heterozygous B-hIL2 but not WT mice.
