CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).
Protein expression analysis
Strain specific IL2RG expression analysis in heterozygous B-hIL2RG mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hIL2RG (H/+) mice, and analyzed by flow cytometry with species-specific anti-IL2RG antibody. Mouse IL2RG was detectable in WT and heterozygous B-hIL2RG mice. Human IL2RG was exclusively detectable in heterozygous B-hIL2RG but not WT mice.