Basic Information

Strain Name
C57BL/6-Ccr1tm1(CCR1)/Bcgen
Common Name
B-hCCR1 mice
Background
C57BL/6N
Catalog number
111191
Aliases
CCR1 (CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hCCR1 mice.

The exon 2 of mouse Ccr1 gene that encode the extracellular domain were replaced by human CCR1 exon 2 in B-hCCR1 mice.

Protein expression analysis

Strain specific CCR1 expression analysis in homozygous B-hCCR1 mice by flow cytometry. Peritoneal exudative macrophages were collected from wild-type mice (+/+) and homozygous B-hCCR1 mice (H/H), and analyzed by flow cytometry with species-specific anti-CCR1 antibody. Mouse CCR1 was detectable in wild-type mice. Human CCR1 was exclusively detectable in homozygous B-hCCR1 but not in wild-type mice.

Protein expression analysis

Human CCR1 was detectable on peritoneal exudative macrophages in homozygous B-hCCR1 mice but not in wild-type mice, and mouse CCR1 was detectable only in wild-type mice.