Basic Information

Strain Name
C57BL/6-Ccr1tm1(CCR1)/Bcgen
Common Name
B-hCCR1 mice
Background
C57BL/6N
Catalog number
111191
Aliases
CCR1 (CKR1, CD191, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hCCR1 mice. Exon 2 of the mouse Ccr1 gene that encodes the extracellular domain was replaced by human CCR1 exon 2 in B-hCCR1 mice.

Protein expression analysis

Species-specific CCR1 protein expression analysis in wild-type and humanized B-hCCR1 mice. Peritoneal exudate macrophages were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCCR1 (H/H) mice and analyzed by flow cytometry using species-specific anti-CCR1 antibodies. Murine CCR1 protein was detected in wild-type mice, while human CCR1 protein was detected in B-hCCR1 mice.