CCR2 ( chemokine (C-C motif) receptor 2 )
NCBI Gene ID
Gene Targeting Strategy
Exon 3 of the murine Ccr2 gene, which encodes the full-length protein domain, was replaced by human CCR2 exons 2-3 in B-hCCR2 mice.
Protein Expression Analysis
Species-specific CCR2 expression analysis in humanized B-hCCR2 mice. Bone marrow was isolated from wild-type C57BL/6 (+/+) and homozygous B-hCCR2 (H/H) mice and analyzed by flow cytometry using species-specific anti-CCR2 antibodies. Human CCR2 protein was exclusively detected in B-hCCR2 mice compared to wild-type mice.