Basic Information
Strain Name
C57BL/6N-Ccr3tm1(CCR3)Bcgen/Bcgen
Common Name
B-hCCR3 mice
Background
C57BL/6N
Catalog number
111401
Aliases
CCR3 (C C CKR3, CC-CKR-3, CD193, CKR 3, CKR3, CMKBR3)
NCBI Gene ID
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Targeting strategy
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Gene targeting strategy for B-hCCR3 mice.
The exon 2 of mouse Ccr3 gene that encode the full-length protein were replaced by human CCR3 exon 3 in B-hCCR3 mice.
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Protein expression analysis
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Strain specific CCR3 expression analysis in homozygous B-hCCR3 mice by flow cytometry. Bone marrow were collected from wild-type mice (+/+) and homozygous B-hCCR3 mice (H/H). Eosinophil were analyzed by flow cytometry with species-specific anti-CCR3 antibody. Mouse CCR3 was detectable in wild-type mice. Human CCR3 was exclusively detectable in homozygous B-hCCR3 mice but not in wild-type mice.
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Summary
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Protein expression analysis:
Mouse CCR3 was detectable in wild-type mice. Human CCR3 was exclusively detectable in homozygous B-hCCR3 mice but not in wild-type mice.
