Basic Information
Strain Name
C57BL/6-Ccr6tm1(CCR6)/Bcgen
Stock Number
110853
Common Name
B-hCCR6 mice
Background
C57BL/6N
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Aliases
BN-1, DCR2, DRY6, CCR-6, CD196, CKRL3, GPR29, CKR-L3, CMKBR6, GPRCY4, STRL22, CC-CKR-6, C-C CKR-6
NCBI Gene ID
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mRNA expression analysis
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Species-specific analysis of CCR6 gene expression in B-hCCR6 mice by RT-PCR. Mouse Ccr6 mRNA was detectable in splenocytes of wild-type mice (+/+). Human CCR6 mRNA was detectable only in homozygous B-hCCR6 mice (H/H) but not in wild-type mice.
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Protein expression analysis
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Species-specific CCR6 expression analysis in humanized B-hCCR6 mice. Splenocytes were collected from wild-type C57BL/6 (+/+) and homozygous B-hCCR6 mice (H/H) and analyzed by flow cytometry using species-specific anti-CCR6 antibodies. Human CCR6 protein was exclusively detected in B-hCCR6 mice compared to wild-type mice.
