Basic Information

Strain Name
C57BL/6-Cxcr2tm1(CXCR2)/Bcgen
Stock Number
110816
Common Name
B-hCXCR2 mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Aliases
C-X-C motif chemokine receptor 2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Species
C57BL/6
Appearance
Black
Genotypes
Heterozygous
NCBI Gene ID

Details

Strain specific analysis of CXCR2 gene expression in WT and B-hCXCR2 mice by RT-PCR. Mouse Cxcr2 mRNA was detectable in splenocytes of wild-type (+/+) mice. Human CXCR2 mRNA was detectable only in H/H, but not in +/+ mice.

Protein expression analysis in Gr-1+ cells in spleen

Strain specific CXCR2 expression analysis in heterozygous B-hCXCR2 mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hCXCR2 (H/H) mice, and analyzed by flow cytometry with species-specific CXCR2 antibody. Mouse CXCR2 was detectable in WT mice and heterozygous B-hCXCR2. Human CXCR2 was exclusively detectable in heterozygous B-hCXCR2 but not WT mice.

Protein expression analysis in Gr-1+ cells in bone marrow

Strain specific CXCR2 expression analysis in heterozygous B-hCXCR2 mice by flow cytometry. Bone marrow were collected from WT and heterozygous B-hCXCR2 (H/H) mice, and analyzed by flow cytometry with species-specific CXCR2 antibody. Mouse CXCR2 was detectable in WT mice and heterozygous B-hCXCR2. Human CXCR2 was exclusively detectable in heterozygous B-hCXCR2 but not WT mice.