Basic Information

Strain Name
C57BL/6-Cxcr6tm1(CXCR6)/Bcgen
Common Name
B-hCXCR6 mice
Background
C57BL/6N
Catalog number
111186
Related Genes
CXCR6 (BONZO, CD186, STRL33, TYMSTR)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hCXCR6 mice. Exon 2 of mouse Cxcr6 gene that encode the extracellular domain was replaced by human CXCR6 exon 2 in B-hCXCR6 mice.

Protein expression analysis in NK cells

Species-specific CXCR6 protein expression analysis in wild-type and humanized B-hCXCR6 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCXCR6 (H/H) mice and analyzed by flow cytometry using species-specific anti-CXCR6 antibodies. Murine CXCR6 protein was detected in wild-type mice, while human CXCR6 protein was detected in B-hCXCR6 mice.

Protein expression analysis in NKT cells

Species-specific CXCR6 protein expression analysis in wild-type and humanized B-hCXCR6 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCXCR6 (H/H) mice and analyzed by flow cytometry using species-specific anti-CXCR6 antibodies. Murine CXCR6 protein was detected in wild-type mice, while human CXCR6 protein was detected in B-hCXCR6 mice.