Basic Information
Strain name
C57BL/6-Gprc5dtm1(GPRC5D)/Bcgen
Common Name
B-hGPRC5D mice
Background
C57BL/6N
Catalog Number
111240
NCBI Gene ID
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Gene targeting strategy
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Gene targeting strategy for B-hGPRC5D mice. The exons 2-4 of mouse Gprc5d gene that encode the full-length protein were replaced by human GPRC5D exons 1-3 in B-hGPRC5D mice.
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Protein expression analysis
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GPRC5D protein expression analysis in wild-type and humanized B-hGPRC5D mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hGPRC5D (H/H) mice, and analyzed by western blot using a cross-reactive anti-m/hGPRC5D antibody. GPRC5D protein was detected in wild-type and B-hGPRC5D mice.
