Basic Information

Strain name
C57BL/6-Axltm1(AXL)/Bcgen
Common Name
B-hAXL mice
Background
C57BL/6J
Catalog Number
110908
NCBI Gene ID
Aliases
AXL (ARK; UFO; JTK11; Tyro7)

Targeting strategy

Gene targeting strategy for B-hAXL mice. The exons 1-11 of mouse Axl gene that encode the extracellular domain were replaced by human AXL exons 1-11 in B-hAXL mice

Protein expression analysis

Strain specific AXL expression analysis in heterozygous B-hAXL mice by flow cytometry. Leukocytes from liver, spleen, lung and kidney were collected from heterozygous B-hAXL mice (H/+) respectively, and analyzed by flow cytometry with human-specific anti-AXL antibody. Human AXL was detectable in heterozygous B-hAXL mice.

Strain specific AXL expression analysis in heterozygous B-hAXL mice by flow cytometry. Leukocytes from liver, spleen, lung and kidney were collected from heterozygous B-hAXL mice (H/+) respectively, and analyzed by flow cytometry with human-specific anti-AXL antibody. Human AXL was detectable in heterozygous B-hAXL mice.

Summary

Protein expression analysis:

Human AXL was detectable in heterozygous B-hAXL mice.