Basic Information
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Targeting strategy
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Gene targeting strategy for B-hAXL mice. The exons 1-11 of mouse Axl gene that encode the extracellular domain were replaced by human AXL exons 1-11 in B-hAXL mice
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Protein expression analysis
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Strain specific AXL expression analysis in heterozygous B-hAXL mice by flow cytometry. Leukocytes from liver, spleen, lung and kidney were collected from heterozygous B-hAXL mice (H/+) respectively, and analyzed by flow cytometry with human-specific anti-AXL antibody. Human AXL was detectable in heterozygous B-hAXL mice.
Strain specific AXL expression analysis in heterozygous B-hAXL mice by flow cytometry. Leukocytes from liver, spleen, lung and kidney were collected from heterozygous B-hAXL mice (H/+) respectively, and analyzed by flow cytometry with human-specific anti-AXL antibody. Human AXL was detectable in heterozygous B-hAXL mice.
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Summary
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Protein expression analysis:
Human AXL was detectable in heterozygous B-hAXL mice.
