Basic Information

Strain name
C57BL/6-Axltm1(AXL)/Bcgen
Common Name
B-hAXL mice
Background
C57BL/6
Catalog Number
110908
NCBI Gene ID
Aliases
AXL (ARK; UFO; JTK11; Tyro7)

Targeting strategy

Gene targeting strategy for B-hAXL mice. The exons 1-11 of mouse Axl gene that encode the extracellular domain were replaced by human AXL exons 1-11 in B-hAXL mice.

Protein expression analysis

Strain specific AXL expression analysis in homozygous B-hAXL mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hAXL mice (H/H). Flow cytometry analysis of the macrophage was analyzed with species-specific anti-AXL antibody. Mouse AXL was detectable in wild-type mice. Human AXL was exclusively detectable in homozygous B-hAXL mice but not in wild-type mice.

Strain specific AXL expression analysis in homozygous B-hAXL mice by flow cytometry. Peritoneal washes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hAXL mice (H/H). Flow cytometry analysis of the macrophage was analyzed with species-specific anti-AXL antibody. Mouse AXL was detectable in wild-type mice. Human AXL was exclusively detectable in homozygous B-hAXL mice but not in wild-type mice.

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