BCM, BCMA, CD269, TNFRSF13A
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hBCMA mice. Exon 1 and part of exon 2, which encode the extracellular region of mouse Bcma gene, were replaced with human BCMA exon 1 and part of exon 2 in B-hBCMA mice.
mRNA expression analysis
Species-specific BCMA gene expression analysis in wild-type and humanized B-hBCMA mice by RT-PCR. Murine Bcma mRNA was detected in splenocytes isolated from wild-type (+/+) mice, while human BCMA mRNA was detected in homozygous B-hBCMA (H/H) mice.