Basic Information

Strain name
C57BL/6-Tnfrsf17tm2(TNFRSF17)Bcgen/Bcgen
Common name
B-hBCMA mice
Catalog number
110899
Background
C57BL/6N
Aliases
BCM, BCMA, CD269, TNFRSF13A
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hBCMA mice. Exon 1 and part of exon 2, which encode the extracellular region of mouse Bcma gene, were replaced with human BCMA exon 1 and part of exon 2 in B-hBCMA mice.

mRNA expression analysis

Strain specific analysis of BCMA gene expression in wild-type C57BL/6 mice and B-hBCMA mice by RT-PCR. Mouse Bcma mRNA was detectable in splenocytes of wild-type C57BL/6 mice (+/+) but not in homozygous B-hBCMA mice (H/H). Human BCMA mRNA was detectable only in homozygous B-hBCMA mice but not in wild-type C57BL/6 mice.

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