Basic Information
Strain name
C57BL/6-Tnfrsf17tm2(TNFRSF17)/Bcgen
Common name
B-hBCMA mice
Catalog number
110899
Background
C57BL/6N
Aliases
BCM, BCMA, CD269, TNFRSF13A
NCBI Gene ID
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Gene targeting strategy
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Gene targeting strategy for B-hBCMA mice. Exon 1 and part of exon 2, which encode the extracellular region of mouse Bcma gene, were replaced with human BCMA exon 1 and part of exon 2 in B-hBCMA mice.
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mRNA expression analysis
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Species-specific BCMA gene expression analysis in wild-type and humanized B-hBCMA mice by RT-PCR. Murine Bcma mRNA was detected in splenocytes isolated from wild-type (+/+) mice, while human BCMA mRNA was detected in homozygous B-hBCMA (H/H) mice.
