Basic Information

Strain name
C57BL/6-Tnfrsf17tm2(TNFRSF17)/Bcgen
Common name
B-hBCMA mice
Catalog number
110899
Background
C57BL/6
Aliases
BCM, BCMA, CD269, TNFRSF13A
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hBCMA mice. The exon 1 and part of exon 2 which encode the extracellular region of mouse Bcma gene were replaced with human BCMA exon 1 and part of exon 2 in B-hBCMA mice.

Details

mRNA expression analysis

Strain specific analysis of BCMA gene expression in wild-type C57BL/6 mice and B-hBCMA mice by RT-PCR. Mouse Bcma mRNA was detectable in splenocytes of wild-type C57BL/6 mice (+/+) but not in homozygous B-hBCMA mice (H/H). Human BCMA mRNA was detectable only in homozygous B-hBCMA mice but not in wild-type C57BL/6 mice.