Basic Information
Strain Name
C57BL/6-Ccr2tm1(CCR2)/Bcgen
Common Name
B-hCCR2 mice
Background
C57BL/6N
Catalog number
110097
Aliases
CCR2 ( chemokine (C-C motif) receptor 2 )
NCBI Gene ID
-
Gene Targeting Strategy
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Gene targeting strategy for B-hCCR2 mice.
The exons 3 of mouse Ccr2 gene that encode the full-length protein domain was replaced by human CCR2 exons 2-3 in B-hCCR2 mice.
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Protein Expression Analysis
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Strain specific CCR2 expression analysis in homozygous B-hCCR2 mice by flow cytometry.
Bone marrow were collected from WT and homozygous B-hCCR2 mice, and analyzed by flow cytometry with species-specific anti-CCR2 antibody. Mouse CCR2 was only detectable in WT mice. Human CCR2 was exclusively detectable in homozygous B-hCCR2 but not WT mice.
