Basic Information

Strain name
C57BL/6-Cd163tm1(CD163)/Bcgen
Common name
B-hCD163 mice
Background
C57BL/6
Catalog number
111298
Aliases
CD163 (M130, MM130, SCARI1)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hCD163 mice. The exons 1-14 of mouse Cd163 gene that encode the extracellular domain and transmembrane domain were replaced by human CD163 exons 1-14 in B-hCD163 mice.

Protein expression analysis

Species-specific CD163 protein expression analysis in wild-type and humanized B-hCD163 mice. Peritoneal exudate macrophages (PEMs) were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCD163 (H/H) mice and analyzed by flow cytometry using species-specific anti-CD163 antibodies. Murine CD163 protein was detected in wild-type mice, while human CD163 protein was detected in B-hCD163 mice.

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