CD200, MOX1, MOX2, MRC, OX-2, CD200 molecule
NCBI Gene ID
Gene targeting strategy
Gene targeting strategy for B-hCD200 mice. The exons 1-5 of mouse Cd200 gene that encode the full-length protein were replaced by human CD200 exons 1-7 in B-hCD200 mice.
Protein expression analysis
Species-specific CD200 protein expression analysis in wild-type and humanized B-hCD200 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and heterozygous B-hCD200 (H/+) mice, and analyzed by flow cytometry using species-specific anti-CD200 antibodies. Murine CD200 protein was detected in wild-type and B-hCD200 mice, while human CD200 protein was only detected in B-hCD200 mice.