Basic Information
Strain name
C57BL/6-Cd200tm1(CD200)/Bcgen
Common name
B-hCD200 mice
Background
C57BL/6
Catalog number
111133
Aliases
CD200, MOX1, MOX2, MRC, OX-2, CD200 molecule
NCBI Gene ID
-
Gene targeting strategy
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Gene targeting strategy for B-hCD200 mice. The exons 1-5 of mouse Cd200 gene that encode the full-length protein were replaced by human CD200 exons 1-7 in B-hCD200 mice.
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Protein expression analysis
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Species-specific CD200 protein expression analysis in wild-type and humanized B-hCD200 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and heterozygous B-hCD200 (H/+) mice, and analyzed by flow cytometry using species-specific anti-CD200 antibodies. Murine CD200 protein was detected in wild-type and B-hCD200 mice, while human CD200 protein was only detected in B-hCD200 mice.
