Basic Information
Strain name
C57BL/6-Cd200r1tm1(CD200R1)/Bcgen
Common name
B-hCD200R mice
Background
C57BL/6N
Catalog number
111131
Aliases
CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCD200R mice.
The exons 2-5 of mouse Cd200r1 gene that encode the extracellular domain were replaced by human CD200R1 exons 2-5 in B-hCD200R mice.
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Protein expression analysis
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Species-specific CD200R protein expression analysis in humanized B-hCD200R mice. Peritoneal exudate macrophages were isolated from wild-type C57BL/6 (+/+) and heterozygous B-hCD200R (H/+) mice, and analyzed by flow cytometry using species-specific anti-CD200R antibodies. Murine CD200R protein was detected in wild-type and heterozygous B-hCD200R (H/+) mice, while human CD200R protein was exclusively detected in B-hCD200R mice.
