Basic Information
Strain name
C57BL/6N-Cd200r1tm1(CD200R1)/Bcgen
Common name
B-hCD200R mice
Background
C57BL/6N
Catalog number
111131
Aliases
CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
NCBI Gene ID
-
Targeting strategy
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Gene targeting strategy for B-hCD200R mice.
The exons 2-5 of mouse Cd200r1 gene that encode the extracellular domain were replaced by human CD200R1 exons 2-5 in B-hCD200R mice.
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Protein expression analysis
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Strain specific CD200R expression analysis in heterozygous B-hCD200R mice by flow cytometry.
Peritoneal exudative macrophages were collected from wild type (WT) mice (+/+) and heterozygous B-hCD200R mice (H/+), and analyzed by flow cytometry with species-specific anti-CD200R antibody. Mouse CD200R was detectable in WT mice (+/+) and heterozygous B-hCD200R mice (H/+). Human CD200R was exclusively detectable in heterozygous B-hCD200R mice (H/+) but not in WT mice (+/+).
