Basic Information

Strain name
C57BL/6-Cd200r1tm1(CD200R1)/Bcgen
Common name
B-hCD200R mice
Background
C57BL/6
Catalog number
111131
Aliases
CD200R1, CD200R, HCRTR2, MOX2R, OX2R, CD200 receptor 1
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hCD200R mice.

The exons 2-5 of mouse Cd200r1 gene that encode the extracellular domain were replaced by human CD200R1 exons 2-5 in B-hCD200R mice.

Protein expression analysis

Strain specific CD200R expression analysis in heterozygous B-hCD200R mice by flow cytometry.

Peritoneal exudative macrophages were collected from wild type (WT) mice (+/+) and heterozygous B-hCD200R mice (H/+), and analyzed by flow cytometry with species-specific anti-CD200R antibody. Mouse CD200R was detectable in WT mice (+/+) and heterozygous B-hCD200R mice (H/+). Human CD200R was exclusively detectable in heterozygous B-hCD200R mice (H/+) but not in WT mice (+/+).

Summary

Protein expression analysis:

Mouse CD200R was detectable in peritoneal exudative macrophages of WT mice (+/+) and heterozygous B-hCD200R mice (H/+). Human CD200R was exclusively detectable in heterozygous B-hCD200R mice (H/+) but not in WT mice (+/+).