Basic Information

Strain Name
C57BL/6-Cd226tm1(CD226)/Bcgen
Stock Number
110869
Common Name
B-hCD226 mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
PTA1; DNAM1; DNAM-1; TLiSA1
Species
C57BL/6
Appearance
Black
Genotypes
Heterozygous

Description

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,and cross-linking CD226 with antibodies causes cellular activation

Details

Protein expression analysis

Strain specific CD226 expression analysis in heterozygous B-hCD226 mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hCD226(H/+) mice and analyzed by flow cytometry with species-specific anti-CD226 antibody. Mouse 226 was detectable in WT and heterozygous B-hCD226 mice. Human CD226 was exclusively detectable in heterozygous B-hCD226 but not WT mice.

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