Basic Information

Strain Name
C57BL/6-Cd38tm3(CD38)/Bcgen
Stock Number
110046
Common Name
B-hCD38 mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
CD38 (cluster of differentiation 38)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Description

CD38 is a 42 kD glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed on B cells, NK cells, a subset of T cells, brain, muscle, and kidney. In mouse, CD38 expression is downregulated on germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and metabolism of cADPR and NAADP. CD31 is the ligand of CD38.

Details

Protein expression analysis

Strain specific CD38 expression analysis in heterozygous B-hCD38 mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hCD38 (H/+) mice, and analyzed by flow cytometry with species-specific anti-CD38 antibody. Mouse CD38 was detectable in WT and heterozygous B-hCD38 mice. Human CD38 was exclusively detectable in heterozygous B-hCD38 but not WT mice.

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