CD38 is a 42 kD glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed on B cells, NK cells, a subset of T cells, brain, muscle, and kidney. In mouse, CD38 expression is downregulated on germinal center B cells and plasma cells, whereas this is not the case for humans. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
Protein expression analysis
Strain specific CD38 expression analysis in heterozygous B-hCD38 mice by flow cytometry. Splenocytes were collected from WT and heterozygous B-hCD38 (H/+) mice, and analyzed by flow cytometry with species-specific anti-CD38 antibody. Mouse CD38 was detectable in WT and heterozygous B-hCD38 mice. Human CD38 was exclusively detectable in heterozygous B-hCD38 but not WT mice.