Basic Information
Strain Name
C57BL/6-Cd52tm1(CD52)/Bcgen
Stock Number
110860
Common Name
B-hCD52 mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Aliases
CD52 (CDW52, EDDM5, HE5)
Species
C57BL/6N
Appearance
Black
Genotypes
Homozygous
NCBI Gene ID
-
mRNA expression analysis
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Species-specific CD52 gene expression analysis in wild-type and B-hCD52 mice by RT-PCR. Murine Cd52 mRNA was detected in splenocytes isolated from wild-type (+/+) mice, while human CD52 mRNA was exclusively detected in B-hCD52 mice.
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Protein expression analysis
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Species-specific CD52 protein expression analysis in humanized B-hCD52 mice. Splenocytes were isolated from wild-type C57BL/6 (+/+) and homozygous B-hCD52 (H/H) mice and analyzed by flow cytometry using species-specific anti-CD52 antibodies. Murine CD52 protein was detected in wild-type mice, while human CD52 protein was exclusively detected in B-hCD52 mice.
