Basic Information

Strain Name
C57BL/6-Cd6tm1(CD6)/Bcgen
Common Name
B-hCD6 mice
Background
C57BL/6N
Catalog number
111145
Related Genes
CD6
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hCD6 mice.  

The exons 2-7 of mouse Cd6 gene that  encode the extracellular domain were replaced by human CD6 exons 2-7 in B-hCD6 mice.

Protein expression analysis

Strain specific CD6 expression analysis in homozygous B-hCD6 mice by flow cytometry. 

Spleen was collected from wild-type mice (+/+) and homozygous B-hCD6 mice(H/H), and analyzed by flow cytometry with species-specific anti-CD6 antibody. Mouse CD6 was detectable in wild-type mice. Human CD6 was exclusively detectable in homozygous B-hCD6 mice but not in wild-type mice.

Summary

Protein  expression:

Human CD6 was exclusively detectable in homozygous B-hCD6 mice but not in wild-type mice.

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