Basic Information
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Protein expression analysis
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Strain specific CSF1 expression analysis in homozygous B-hCSF1/hCSF1R mice by ELISA. Splenocytes were collected from WT and homozygous B-hCSF1/hCSF1R (H/H) mice stimulated with LPS in vivo, and analyzed by ELISA with species-specific anti-CSF1 ELISA kit. Mouse CSF1 was detectable in WT. Human CSF1 was exclusively detectable in homozygous B-hCSF1/hCSF1R but not WT mice.
Strain specific CSF1R expression analysis in homozygous B-hCSF1/hCSF1R mice by flow cytometry. Blood were collected from WT and homozygous B-hCSF1/hCSF1R (H/H) mice, and analyzed by flow cytometry with species-specific anti-CSF1R antibody. Mouse CSF1R was detectable in WT .Human CSF1R was exclusively detectable in homozygous B-hCSF1/hCSF1R but not WT mice.
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Poster
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AACR 2022: Evaluation of Therapeutic Drug Candidates Using a Novel Humanized B-hCSF1/hCSF1R
