B-hCSF1R mice

Basic Information

Strain name
C57BL/6-Csf1rm1(CSF1R)/Bcgen
Common name
B-hCSF1R mice
Background
C57BL/6
Catalog number
110035
Related genes
CSF1R

Description

CSF1R(Colony-stimulating factor 1 receptor) , also known as CD115 and M-CSF-R, CSF1R belongs to the type Ⅲ protein tyrosine kinase receptor family is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. This gene product’s natural ligands include CSF1 and IL-34. CSF1R directly influences tissue macrophage and osteoclast differentiation and proliferation. CSF1R mediated signaling is crucial for the differentiation and survival of the mononuclear phagocyte system and macrophages in particular.

Details

Protein expression analysis

Strain specific CSF1R expression analysis in heterozygous B-hCSF1R mice by flow cytometry. Blood were collected from WT and heterozygous B-hCSF1R (H/+) mice, and analyzed by flow cytometry with species-specific anti-CSF1R antibody. Mouse CSF1R was detectable in WT and heterozygous B-hCSF1R mice. Human CSF1R was exclusively detectable in heterozygous B-hCSF1R but not WT mice.

Back to top