B-hCTLA4/hLAG3 Mice

Basic Information

Strain Name
C57BL/6-Ctla4tm1(CTLA4) Lag3tm1(LAG3)/Bcgen
Stock Number
120529
Common Name
B-hCTLA4/hLAG3 Mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
Ctla4 (cytotoxic T-lymphocyte-associated protein 4); Lag3 (lymphocyte-activation gene 3)
Species
C57BL/6
Appearance
Black
Genotypes
Homozygous

Targeting Strategy

B-hCTLA4-hLAG3-Mice

Detail

Phenotype

Protein Expression Analysis

 

Splenocytes from both wild type (WT) C57BL/6 and homozygous B-hCTLA4/hLAG3 mice were analyzed by flow cytometry.
Mouse LAG3+ T cells were detectable in both WT C57BL/6 and the homozygous B-hCTLA4/hLAG3 mice, while human LAG3+ T cells were detectable in the homozygous B-hCTLA4/hLAG3 mice. This might be a result from the cross-recognition of hLAG3 by anti-mLAG3 antibodies.

 

References

  1. Cell Research (2018) 0:1–15; doi: 10.1038/s41422-018-0012-z
  2. Cancer Immunity (22 January 2013) Vol. 13, p. 5
  3. Journal of Immunological Methods, 18 November 2016. doi: 10.1016/j.jim.2017.04.006
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