Basic Information
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Targeting Strategy
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Details
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Phenotype
Protein Expression Analysis
Splenocytes B-hCTLA4/hOX40 mice were analyzed by flow cytometry. Mouse CTLA4+ cells were detectable in WT C57BL/6, while human CTLA4+ cells were detectable in the homozygous B-hCTLA4/hOX40 mice.
Splenocytes from homozygous B-hCTLA4/hOX40 mice were analyzed by flow cytometry. Mouse OX40+ cells were detectable in wild type (WT) C57BL/6, while human OX40+ cells were detectable in the homozygous B-hCTLA4/hOX40 mice.
Application
Combination Therapy of CTLA4 mAb (Ipilimumab) and OX40 mAb
Anti-tumor activity of anti-human CTLA4 antibody combined with anti-human OX40 antibody in humanized B-hCTLA4/hOX40 mice. (A) Murine colon cancer MC38 cells were subcutaneously implanted into homozygous B-hCTLA4/hOX40 mice (female, 5-8-week-old, n=8). Anti-human CTLA4 (Ipilimumab) antibody combined with anti-human OX40 antibody significantly inhibited MC38 tumor growth in B-hCTLA4/hOX40 mice, (B) without negatively impacting body weight changes.
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References
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- J Exp Med. 1991 Sep 1;174(3):561-9.
- Immunol Cell Biol. 1999 Feb;77(1):1-10.
- Blood. 2005 Nov 1;106(9):3127-33. Epub 2005 Jul 21.
- Clin Transl Immunology. 2014 Aug 1;3(8): e22. doi: 10.1038/cti.2014.18. eCollection 2014 Aug.
