Basic Information
Strain Name
C57BL/6-Dll4tm3(DLL4)/Bcgen
Common Name
B-hDLL4 mice
Background
C57BL/6
Catalog number
112067
Aliases
DLL4, AOS6, delta4, hdelta2, delta like canonical Notch ligand 4
NCBI Gene ID
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Gene targeting strategy
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Gene targeting strategy for B-hDLL4 mice.
The exons 2-9 of mouse Dll4 gene that encode the extracellular domain were replaced by human DLL4 exons 2-9 in B-hDLL4 mice.
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mRNA expression analysis
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Strain specific analysis of DLL4 gene expression in wild type (WT) mice and B-hDLL4 mice by RT-PCR.
Mouse Dll4 mRNA was detectable only in heart and lung of WT mice (+/+). Human DLL4 mRNA was detectable only in homozygous B-hDLL4 mice (H/H) but not in WT mice (+/+).
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Summary
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mRNA expression analysis:
Mouse Dll4 mRNA was detectable only in heart and lung of WT mice (+/+). Human DLL4 mRNA was detectable only in homozygous B-hDLL4 mice (H/H) but not in WT mice (+/+).
