Basic Information

Strain name
C57BL/6-Fgl2tm1(FGL2)/Bcgen
Common name
B-hFGL2 mice
Background
C57BL/6N
Catalog number
111190
Aliases
FGL2 (T49, pT49)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-hFGL2 mice. The exons 1-2 of mouse Fgl2 gene that encode the full-length protein were replaced by human FGL2 exons 1-2 in B-hFGL2 mice.

mRNA expression analysis

Species-specific FGL2 gene expression analysis in wild-type and humanized B-hFGL2 mice by RT-PCR. Murine Fgl2 mRNA was detected in peritoneal exudate macrophages isolated from wild-type (+/+) mice, while human FGL2 mRNA was detected in homozygous B-hFGL2 (H/H) mice.