Basic Information

Strain name
C57BL/6Klbtm1(KLB)/Bcgen
Common name
B-hKLB mice
Background
C57BL/6
Catalog Number
110839
Aliases
BKL, KLB
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hKLB mice. The exons 1-5 of mouse Klb gene that encode the extracellular domain were replaced by human KLB exons 1-5 in B-hKLB mice.

Protein expression analysis

Strain specific analysis of KLB expression in heterozygous B-hKLB  mice by Western blot.

Mouse KLB was detectable both in liver of wild type (+/+) mice and heterozygous B-hKLB  mice. Human KLB was detectable in heterozygous B-hKLB  mice (H/+) , HepG2 cells, and Hep3B cells but not in +/+ mice. HepG2 and Hep3B cells were used as positive control there.